Meeting aseptic challenges: 3P innovation’s success with Asyril and the Asycube Clean 230
3P innovation adopts Asycube Clean 230 to bring flexibility to aseptic manufacturing
3P innovation is a leading provider of advanced automation solutions and processes tailored for the pharmaceutical and medical device industries.
Facing increasing regulatory demands and the need to meet GMP (Good Manufacturing Practices) Annex 1 standards, 3P Innovation sought an aseptic version of the Asyril Asycube feeder that could ensure compliance while aligning with evolving market expectations.
Through a close and efficient collaboration with Asyril, 3P innovation successfully integrated the Asycube Clean 230 into its aseptic manufacturing solutions, delivering performance, sterility, and flexibility in a single system.
Challenges
- Small batch manufacturing: batch sizes in the pharmaceutical industry are becoming increasingly smaller. Blockbuster drugs are less common or require less specialized handling.
- Low volume production, addressing the needs of rare disease treatments and personalized healthcare, requiring frequent changeovers.
- High sterility requirements: the pharmaceutical industry must comply with strict standards, including GMP Annex 1 regulations.
- Safety: robot-assisted environments ensure safer operations with no direct human contact, especially in pharmaceutical settings.
Solution
- The Asycube Clean 230 was selected for its gentle component separation, enabled by patented 3-axis vibration technology, and its full compatibility with aseptic, sterile and pharmaceutical environments.
- In this specific case two Asycube Clean 230 were integrated by 3P innovation in a compact solution to feed the stoppers and caps.
- The Stäubli Stericlean robot was selected for its high precision, reliability, and full compatibility with sterile and pharmaceutical environments.
- The combination of the Asycube Clean 230 and the Stäubli Stericlean Robot enable the automatic process of filling, stoppering, caping and crimping.
Advantages for 3P Innovation
- Market expansion: aseptic-ready feeder Asycube Clean 230 enables entry into flexible sterile and cleanroom manufacturing.
- Sterility assurance: FDA-compliant material and easy-to-clean design minimizes contamination risk.
- RTP compatible: Asycube platform made of PEEK supports sterile transfer processes and is compact enough to be transfered inside the isolator through Rapid Transfer Port (RTP).
- Flexibility: fast product changeovers with quick reprogramming.
- Adaptability: handles diverse components without custom tooling.
- Precision & care: accurate pick-and-place with gentle vibrations.
“Traditional component feeding technologies for sterile applications have been struggling to meet the demands of regulators for many years, particularly with the latest Annex 1 regulations. Traditional methods force compromises to be made which increase risk of contamination of critical components. Asyril’s Asycube product is a long overdue and welcome introduction to the pharmaceutical industry, enabling a new era of flexible, high sterility assurance component feeding.”
Alex Jezequel, Projects Director, 3P innovation
